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KMID : 0352519860230030107
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Korea Univercity Medical Journal
1986 Volume.23 No. 3 p.107 ~ p.113
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Determination of antibodies against Hantaan and Seoul viruses in sera from patients of hemorrhagic fever with renal syndrome by immune adherence hemagglutination test
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Abstract
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Immune adherence hemagglutination (IAHA) test was used to investigate the production of antibodies against Hantaan (HTN/83-138) and Seoul (SE0180-39) viruses in sera from Hemorrhagic fever with´renal syndrome (HFRS) patients who were infected with Hantaan virus in Korea.
The five patients diagnosed as typical HFRS have been bled at weekly intervals starting from 3 days after onset of disease up to 66 days. Sera were tested to determine the titers of antibodies as well as the reactivities against Hantaan and Seoul viral antigens.
The results are as follows;
1. IAHA antibodies against Hantaan viral antigen: The antibodies increasing from 3 days after the onset of disease were reached at peaks around one week later. The antibody titers were rised rapidly and the peak titers were reached at around 2 weeks after the disease and persisted for 2-3 weeks. Thereafter the titer were decreased slowly.
Y 2. IAHA antibodies against Seoul viral antigen: The antibodies were detectable at as earlier days as 3 days after the onset of disease. The titers of antibody were peaked at around one week later and persisted with same level of titers until 2 months. However the titers of antibody were not as high as those against Hantaan viral antigen.
3. Reactivities of HFRS sera against Hantaan and Seoul viral antigens: The reactivity was always 4-16 times higher with Hantaan viral antigen than with Seoul viral antigen in all sera tested except the sera from very early days. The clear differences in reactivity between Hantaan and Seoul viral antigens were observed in all sera used regardless of times for bleeding suggesting homologous relationship between Hantaan virus and antibodies in sera of HFRS patients.
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KEYWORD
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